When wanting to block a list of URL's globally as one of the first rules, an admin cannot or may not want to use a URL Filtering profile because of the following reasons:
It prevents other URL filtering in the rest of the policy.
There is no way to use FQDN objects for domains like "*.google.com", as the wildcard is not allowed for a FQDN object.
Resolution
In order to block a list of URL's globally, create a custom URL category and add URL's to the category and then place that into a rule.
Create a Custom URL Category by going to Objects > Custom Objects > URL Category. Click 'Add' on the bottom-left part of the screen, give it a Name and Description(optional), then 'Add' the URL's as needed. Note: Please remember there is a difference between site.com and *.site.com
Add the Custom URL Category into a rule by using the "URL Category" section located in Service/URL Category tab when creating a new rule: By blocking sites with the URL Category, this still allows other URL Filtering Profiles to be applied to later rules.